BDBM50431135 CHEMBL2332065

SMILES COc1cccc(CN(CCO)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1

InChI Key InChIKey=NGOKTEXAUPRBFP-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50431135   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Shanghai Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50431135(CHEMBL2332065)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF modeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Shanghai Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50431135(CHEMBL2332065)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF modeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50431135(CHEMBL2332065)
Affinity DataIC50:  6nMAssay Description:Inhibition of ROCK1 (unknown origin) after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50431135(CHEMBL2332065)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)-mediated tolbutamide hydroxylation to hydroxy tolbutamideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50431135(CHEMBL2332065)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of JNK3 alpha1 (unknown origin) using biotinylated Flag-ATF2 as substrate after 15 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50431135(CHEMBL2332065)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)-mediated bufuralol hydroxylation to 4'-HydroxybufuralolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50431135(CHEMBL2332065)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)-mediated midazolam hydroxylation to 1'-HydroxymidazolamMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50431135(CHEMBL2332065)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP1A2 (unknown origin)-mediated phenaceten demethylation to acetaminophenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase MRCK alpha(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50431135(CHEMBL2332065)
Affinity DataIC50:  4.31E+3nMAssay Description:Inhibition of MRCKalpha (unknown origin) using LCD-AKRRRRLSSLRA-NH2 as substrate after 75 mins by luminescence assay in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Shanghai Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50431135(CHEMBL2332065)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 (unknown origin) after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed