BDBM50432472 CHEMBL2349340

SMILES Cc1[nH]nc2[C@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-c12)c1ccc(Cl)cc1

InChI Key InChIKey=OTQMKIIOHSXWSJ-KRWDZBQOSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50432472   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50432472(CHEMBL2349340)
Affinity DataIC50:  59nMAssay Description:Displacement of FITC-labeled (+)-JQ1 from bromodomain BRD4(1) (unknown origin) expressed in Escherichia coli BL21(DE3) after 4 hrs by fluorescence an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50432472(CHEMBL2349340)
Affinity DataIC50:  360nMAssay Description:Inhibition of bromodomain BRD4-mediated c-myc mRNA expression in human HT-29 cells after 24 hrs by RT-qPCR analysis relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed