BDBM50432661 CHEMBL2347398::US11407721, Example 1 Step B

SMILES CN1[C@@H]([C@@H](OCC1=O)c1ccc(Br)cc1)c1ccc(Br)cc1

InChI Key InChIKey=OUTBUVLNDIYGFF-SJORKVTESA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50432661   

TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50432661(CHEMBL2347398 | US11407721, Example 1 Step B)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50432661(CHEMBL2347398 | US11407721, Example 1 Step B)
Affinity DataIC50:  3.46E+4nMAssay Description:This assay was run using the same conditions as the HTRF1 assay except that 20 uL of GST-hMDM2 was incubated with 1.0 ul of diluted compound.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50432661(CHEMBL2347398 | US11407721, Example 1 Step B)
Affinity DataIC50:  5.41E+3nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In DepthDetails US Patent