BDBM50435522 CHEMBL2392480

SMILES N#CCCN[C@H]1CC[C@@H](CC1)n1nnc2cnc3[nH]ccc3c12

InChI Key InChIKey=HFCJAKGWADMYJC-HAQNSBGRSA-N

Data  3 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50435522   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50435522(CHEMBL2392480)
Affinity DataKi:  5.90nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50435522(CHEMBL2392480)
Affinity DataKi:  21nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50435522(CHEMBL2392480)
Affinity DataKi:  122nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50435522(CHEMBL2392480)
Affinity DataEC50:  165nMAssay Description:Inhibition of JAK1-mediated STAT3 phosphorylation in IL6-induced human TF1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed