BDBM50438864 CHEMBL2420507

SMILES Oc1cccc(c1)-n1c2cc(ccc2cc2c1nc(=O)[nH]c2=O)C#N

InChI Key InChIKey=ZGRZTJZRHOLFOO-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50438864   

TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50438864(CHEMBL2420507)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of APE-1 (unknown origin) using double-stranded AP-site containing DNA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50438864(CHEMBL2420507)
Affinity DataIC50:  42nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50438864(CHEMBL2420507)
Affinity DataEC50:  50nMAssay Description:Inhibition of TDP2 (unknown origin) using 4-nitrophenyl phenylphosphonate as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50438864(CHEMBL2420507)
Affinity DataIC50:  520nMAssay Description:Inhibition of TDP2 (unknown origin) using 5'-Y-TCCGTTGAAGCCTGCTTT-3' as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed