BDBM50442595 CHEMBL2441408::US9056859, 12

SMILES O=C(Cc1ccc(cc1)-n1cnnn1)N1CCN(CCc2ccc3C(=O)OCCc3c2)CC1

InChI Key InChIKey=UTGNVKDQKQTRCO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50442595   

TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50442595(CHEMBL2441408 | US9056859, 12)
Affinity DataIC50:  61nMpH: 7.4Assay Description:Block of Kir1.1 (ROMKI) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442595(CHEMBL2441408 | US9056859, 12)
Affinity DataIC50:  61nMAssay Description:Inhibition of human ROMK channel by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50442595(CHEMBL2441408 | US9056859, 12)
Affinity DataIC50:  199nMAssay Description:Inhibition of rat ROMK channel-mediated 86Rb+ fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442595(CHEMBL2441408 | US9056859, 12)
Affinity DataIC50:  240nMAssay Description:Inhibition of human ROMK channel-mediated 86Rb+ flux expressed in CHO cells after 35 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed