BDBM50450871 CHEMBL4205392
SMILES CCn1cnc2c(Nc3cn(C)nc3OC)nc(nc12)N1C[C@@H](F)[C@@H](C1)NC(=O)C=C
InChI Key InChIKey=TVZDMLIBOQCFAB-VXGBXAGGSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50450871
Affinity DataKi: 6nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 83nMAssay Description:Inhibition of EGF-stimulated wild-type EGFR phosphorylation in human A549 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by san...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of EGFR T790M/L858R double mutant phosphorylation in human H1975 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by s...More data for this Ligand-Target Pair