BDBM50450873 CHEMBL4206312
SMILES CC(C)n1cnc2c(Nc3ccc(cc3)N3CCN(C)CC3)nc(N[C@@H]3CCN(C3)C(=O)C=C)nc12
InChI Key InChIKey=GSLCJCBURXKYPH-HXUWFJFHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50450873
Affinity DataKi: 32nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 387nMAssay Description:Inhibition of EGF-stimulated wild-type EGFR phosphorylation in human A549 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by san...More data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of EGFR T790M/L858R double mutant phosphorylation in human H1975 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by s...More data for this Ligand-Target Pair