BDBM50459439 CHEMBL4215257
SMILES Cc1cc(Cn2c(nc3c(cc(Cl)cc23)N2CCC[C@H]2CN)N2CCNCC2)cc(C)c1F
InChI Key InChIKey=CAPZSPOPEHSYOZ-FQEVSTJZSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50459439
Affinity DataEC50: 7.30E+3nMAssay Description:Activation of SOS1 in human NCI-H727 cells expressing KRAS G12V mutant assessed as induction of ERK1/2 T202/Y204 phosphorylation incubated for 30 min...More data for this Ligand-Target Pair
Affinity DataEC50: 3.20E+3nMAssay Description:Activation of SOS1 in human HeLa cells expressing wild type KRAS assessed as induction of ERK1/2 T202/Y204 phosphorylation incubated for 30 mins by I...More data for this Ligand-Target Pair
Affinity DataKd: 140nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair