BDBM50459439 CHEMBL4215257

SMILES Cc1cc(Cn2c(nc3c(cc(Cl)cc23)N2CCC[C@H]2CN)N2CCNCC2)cc(C)c1F

InChI Key InChIKey=CAPZSPOPEHSYOZ-FQEVSTJZSA-N

Data  1 Kd  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50459439   

TargetSon of sevenless homolog 1(Homo sapiens (Human))
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459439(CHEMBL4215257)
Affinity DataEC50:  7.30E+3nMAssay Description:Activation of SOS1 in human NCI-H727 cells expressing KRAS G12V mutant assessed as induction of ERK1/2 T202/Y204 phosphorylation incubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459439(CHEMBL4215257)
Affinity DataEC50:  3.20E+3nMAssay Description:Activation of SOS1 in human HeLa cells expressing wild type KRAS assessed as induction of ERK1/2 T202/Y204 phosphorylation incubated for 30 mins by I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459439(CHEMBL4215257)
Affinity DataKd:  140nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB