BDBM50459714 CHEMBL4204710::US10836764, Compound 149

SMILES [H][C@]12CCc3c(ccnc3N1CCNC2)C1CCC1

InChI Key InChIKey=QRFXLVHUVBURRJ-GFCCVEGCSA-N

Data  3 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50459714   

Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50459714(CHEMBL4204710 | US10836764, Compound 149)
Affinity DataKi:  1.41nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50459714(CHEMBL4204710 | US10836764, Compound 149)
Affinity DataKi:  2.27nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50459714(CHEMBL4204710 | US10836764, Compound 149)
Affinity DataKi:  10.3nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50459714(CHEMBL4204710 | US10836764, Compound 149)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50459714(CHEMBL4204710 | US10836764, Compound 149)
Affinity DataEC50:  236nMAssay Description:Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50459714(CHEMBL4204710 | US10836764, Compound 149)
Affinity DataEC50:  22nMAssay Description:Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed