BDBM50459880 CHEMBL4226570

SMILES Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]2N=C(c3c(C)c(C)sc3-n3c(C)nnc23)c2ccc(Cl)cc2)C(C)(C)C)cc1

InChI Key InChIKey=PTAMRJLIOCHJMQ-PYNGZGNASA-N

Data  1 KI  1 IC50  15 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50459880   

TargetElongin-C(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKi:  282nMAssay Description:Displacement of (2S,4R)-N-(4-bromobenzyl)-4-hydroxy-1-(3,3,3-trifluoropropanoyl)pyrrolidine-2-carboxamide from VBC E3 ligase (unknown origin) binary ...More data for this Ligand-Target Pair
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))TBA
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  66nMAssay Description:Binding affinity to VHL (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))TBA
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  34nMAssay Description:Binding affinity to N-terminal His6-tagged VHL (54 to 213 residues) (unknown origin) expressed in Escherichia coli assessed as displacement of HIF-1a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetElongin-C(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataIC50:  882nMAssay Description:Displacement of (2S,4R)-N-(4-bromobenzyl)-4-hydroxy-1-(3,3,3-trifluoropropanoyl)pyrrolidine-2-carboxamide from VBC E3 ligase (unknown origin) binary ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))TBA
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  307nMAssay Description:Binding affinity to BRD2 BD1 domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))TBA
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  228nMAssay Description:Binding affinity to BRD2 BD2 domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))TBA
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  119nMAssay Description:Binding affinity to BRD3 BD1 domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))TBA
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  115nMAssay Description:Binding affinity to BRD3 BD2 domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  382nMAssay Description:Binding affinity to BRD4 BD1 domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  120nMAssay Description:Binding affinity to BRD4 BD2 domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))TBA
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  115nMAssay Description:Binding affinity to BRD2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))TBA
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  115nMAssay Description:Binding affinity to BRD3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  115nMAssay Description:Binding affinity to BRD4 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataEC50:  150nMAssay Description:Activation of caspase 3/7 in human 22Rv1 cells by Caspase-Glo reagent based analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  740nMAssay Description:Binding affinity to BRD4 BD2 (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))TBA
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  740nMAssay Description:Binding affinity to BRD2 BD1 (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetElongin-C(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  69nMAssay Description:Binding affinity to N-terminal His6-tagged recombinant human VHL (54 to 213 residues)/elongin C (17 to 112 residues)/elongin B (1 to 104 residues) ex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  26nMAssay Description:Binding affinity to N-terminal His6-tagged recombinant human Brd4 BD2 expressed in Escherichia coli BL21 (DE3) assessed as compound binary complex fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed