BDBM50459952 CHEMBL4226127::US10730870, Example 108::US11512083, Example 108

SMILES CN([C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C)C(C)=O

InChI Key InChIKey=IIPLOHQVELTIPV-RZUBCFFCSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50459952   

TargetElongin-C(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50459952(CHEMBL4226127 | US10730870, Example 108 | US115120...)
Affinity DataKd:  5.50E+3nMAssay Description:Displacement of FAM-labeled HIF-1alpha peptide from VBC (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetVHL complex(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM50459952(CHEMBL4226127 | US10730870, Example 108 | US115120...)
Affinity DataIC50:  3.35E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM50459952(CHEMBL4226127 | US10730870, Example 108 | US115120...)
Affinity DataIC50:  3.35E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent