BDBM50466660 CHEMBL4281393

SMILES N#CN[C@H]1CCc2ccc(cc12)-c1ncnc2[nH]ccc12

InChI Key InChIKey=RBDSMNWWGHWDMP-AWEZNQCLSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50466660   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466660(CHEMBL4281393)
Affinity DataIC50:  256nMAssay Description:Inhibition of recombinant human GST-tagged JAK3 JH1 domain using KAIETDKEYYTVKD-NH2 as substrate in presence of 1 mM ATP concentration by coupled PK/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466660(CHEMBL4281393)
Affinity DataIC50:  82nMAssay Description:Inhibition of recombinant human GST-tagged JAK1 using KAIETDKEYYTVKD-NH2 as substrate in presence of ATP at Km concentration by coupled PK/LDH assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466660(CHEMBL4281393)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BLK (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466660(CHEMBL4281393)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human GST-tagged JAK3 JH1 domain using KAIETDKEYYTVKD-NH2 as substrate in presence of ATP at Km concentration by coupled PK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466660(CHEMBL4281393)
Affinity DataIC50:  598nMAssay Description:Inhibition of JAK3 in human PBMC assessed as reduction in IL15-induced STAT5 phosphorylation preincubated for 75 mins followed by IL15 addition and m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466660(CHEMBL4281393)
Affinity DataIC50:  6.31E+3nMAssay Description:Inhibition of BMX (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466660(CHEMBL4281393)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BTK (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466660(CHEMBL4281393)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466660(CHEMBL4281393)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HER2 (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466660(CHEMBL4281393)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HER4 (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466660(CHEMBL4281393)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MAP2K7 (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466660(CHEMBL4281393)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TEC (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466660(CHEMBL4281393)
Affinity DataIC50:  1.67E+3nMAssay Description:Inhibition of recombinant human GST-tagged JAK2 using KAIETDKEYYTVKD-NH2 as substrate in presence of 1 mM ATP concentration by coupled PK/LDH assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466660(CHEMBL4281393)
Affinity DataIC50:  1.84E+3nMAssay Description:Inhibition of recombinant human His-tagged TYK2 expressed in SF21/baculovirus expression system using KAIETDKEYYTVKD-NH2 as substrate in presence of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466660(CHEMBL4281393)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ITK (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466660(CHEMBL4281393)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK3 in human whole blood assessed as reduction in IL15-induced STAT5 phosphorylation preincubated for 75 mins followed by IL15 additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50466660(CHEMBL4281393)
Affinity DataIC50:  2.82E+3nMAssay Description:Inhibition of JAK1/TYK2 in human PBMC assessed as reduction in IL10-induced STAT3 phosphorylation preincubated for 75 mins followed by IL10 addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466660(CHEMBL4281393)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TXK (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466660(CHEMBL4281393)
Affinity DataIC50:  644nMAssay Description:Inhibition of recombinant human GST-tagged JAK1 using KAIETDKEYYTVKD-NH2 as substrate in presence of 1 mM ATP concentration by coupled PK/LDH assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed