BDBM50467472 CHEMBL4281766
SMILES [H][C@@]12Cc3c([nH]c4ccccc34)[C@H](N1C(=O)N(CC)C2=O)c1ccc(CC)o1
InChI Key InChIKey=VKKJMPZSQBNIOL-QFBILLFUSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50467472
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Rattus norvegicus)
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataEC50: 63nMAssay Description:Inhibition of PDE5 in Wistar rat mesentric arteries assessed as inhibition of phenylephrine-induced contraction by measuring increase in acetylcholin...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE4A1A expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as su...More data for this Ligand-Target Pair
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE9A2 expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as sub...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PDE2A (2 to 941 residues) expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AM...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PDE3B (592 to end residues) expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-A...More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE1A expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PDE7A (122 to end residues) expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-A...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-A...More data for this Ligand-Target Pair
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE11A4 expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as su...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE8A1 expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as sub...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE5A1 expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-GMP as sub...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: 127nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair