BDBM50496800 CHEMBL3218036
SMILES COc1cc2ccccc2nc1COc1ccc(cc1)-c1nn(C)cc1-c1ccncc1
InChI Key InChIKey=DMJIVIUKEVILJD-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50496800
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 3.85E+3nMAssay Description:Inhibition of human recombinant PDE4A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
Affinity DataKd: 1.30nMAssay Description:Binding affinity to PDE10A in rat striatum homogenateMore data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.23E+5nMAssay Description:Inhibition of human recombinant PDE3A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 3.43E+3nMAssay Description:Inhibition of human recombinant PDE4B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 8.27E+4nMAssay Description:Inhibition of human recombinant PDE3B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair