BDBM50496811 CHEMBL3222274

SMILES COc1cc(COc2ccc(cc2)-c2c(cnn2C)-c2ccncc2)nc2ccccc12

InChI Key InChIKey=XSKPTAUZCSEXAS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50496811   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Washington University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50496811(CHEMBL3222274)
Affinity DataIC50:  5.06E+3nMAssay Description:Inhibition of human recombinant PDE4B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Washington University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50496811(CHEMBL3222274)
Affinity DataIC50:  4.18E+3nMAssay Description:Inhibition of human recombinant PDE4A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50496811(CHEMBL3222274)
Affinity DataIC50:  0.360nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Washington University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50496811(CHEMBL3222274)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of human recombinant PDE3B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Washington University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50496811(CHEMBL3222274)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of human recombinant PDE3A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed