BDBM50496812 CHEMBL3222276

SMILES COc1ccc2nc(COc3ccc(cc3)-c3c(cnn3C)-c3ccncc3)ccc2c1

InChI Key InChIKey=PIPWLEHQKVJFAH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50496812   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Washington University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50496812(CHEMBL3222276)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human recombinant PDE4A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50496812(CHEMBL3222276)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Washington University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50496812(CHEMBL3222276)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human recombinant PDE3A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Washington University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50496812(CHEMBL3222276)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human recombinant PDE3B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Washington University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50496812(CHEMBL3222276)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of human recombinant PDE4B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed