BDBM50496812 CHEMBL3222276
SMILES COc1ccc2nc(COc3ccc(cc3)-c3c(cnn3C)-c3ccncc3)ccc2c1
InChI Key InChIKey=PIPWLEHQKVJFAH-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50496812
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human recombinant PDE4A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human recombinant PDE3A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human recombinant PDE3B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of human recombinant PDE4B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair