BDBM50501645 CHEMBL4084281

SMILES Fc1cccc(c1)-c1nn2c(Cn3nnc4ccccc34)nnc2s1

InChI Key InChIKey=HNYXILOYZDAKIG-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50501645   

TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50501645(CHEMBL4084281)
Affinity DataIC50:  2.81E+4nMAssay Description:Inhibition of DOT1L in human KOPN8 cells assessed as reduction in cell viability after 72 hrs by alamar blue assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50501645(CHEMBL4084281)
Affinity DataIC50:  5.58E+4nMAssay Description:Inhibition of DOT1L in human THP-1 cells assessed as reduction in cell viability after 72 hrs by alamar blue assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50501645(CHEMBL4084281)
Affinity DataIC50:  8.29E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) at preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50501645(CHEMBL4084281)
Affinity DataKd:  1.73E+4nMAssay Description:Binding affinity to human N-terminal 6His-tagged DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) after 150 secs by SPR-based bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50501645(CHEMBL4084281)
Affinity DataIC50:  2.19E+4nMAssay Description:Inhibition of DOT1L in human MV4-11 cells assessed as reduction in cell viability after 72 hrs by alamar blue assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed