BDBM50501827 CHEMBL4575227

SMILES NC(=O)c1cccc2C(=O)\C(Oc12)=C\c1ccc(cc1)C(=O)N1CCn2c(C1)nnc2C1CC1

InChI Key InChIKey=JJCAYWVTBMMQMQ-UNOMPAQXSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50501827   

TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50501827(CHEMBL4575227)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 insect cells using histone as substrate mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50501827(CHEMBL4575227)
Affinity DataIC50:  27nMAssay Description:Inhibition of human full-length N-terminal GST-tagged PARP1 expressed in baculovirus infected Sf9 insect cells using histone as substrate measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50501827(CHEMBL4575227)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 insect cells using histone as substrate mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50501827(CHEMBL4575227)
Affinity DataIC50:  27nMAssay Description:Inhibition of human full-length N-terminal GST-tagged PARP1 expressed in baculovirus infected Sf9 insect cells using histone as substrate measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB