BDBM50502486 CHEMBL4468997::US11834430, Compound 5

SMILES Cc1nccn1-c1cccc(OCCOc2ccc(cc2Cl)C#N)c1

InChI Key InChIKey=WJVPADFVXZPWNZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50502486   

TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM50502486(CHEMBL4468997 | US11834430, Compound 5)
Affinity DataIC50:  3nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM50502486(CHEMBL4468997 | US11834430, Compound 5)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed