BDBM50502716 CHEMBL4576494::US11440915, Example 11

SMILES Cc1cn(cn1)C12CCC(CC1)(CC2)Nc1nc2[C@H](CCCCn2n1)c1ccc(F)c(F)c1

InChI Key InChIKey=SHMFPLIJEKPQEZ-PNEAOOGRSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50502716   

TargetIsoform APP695 of Amyloid-beta precursor protein [K595N,M596L](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50502716(CHEMBL4576494 | US11440915, Example 11)
Affinity DataEC50:  39nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50502716(CHEMBL4576494 | US11440915, Example 11)
Affinity DataIC50:  39nMAssay Description:Inhibition of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed