BDBM50503462 CHEMBL4527834
SMILES C[C@H]1CN(Cc2cc3nc(cc(-c4ccc(F)cc4)c3s2)C(N)=O)C[C@@H](C)O1
InChI Key InChIKey=CGOSJAXPXSHPEA-BETUJISGSA-N
Data 9 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50503462
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of human mGlu5R expressed in Trex293 cells assessed as decrease in glutamate-induced calcium mobilization preincubated...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 550nMAssay Description:Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of rat mGlu3R expressed in Trex cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobiliz...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 6(Homo sapiens (Human))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of human mGlu6 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of rat mGlu4 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux p...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 8(Rattus norvegicus (Rat))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of rat mGlu8 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux p...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of human mGlu1R expressed in Trex293 cells assessed as decrease in glutamate-induced calcium mobilization preincubated...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 550nMAssay Description:Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Vanderbilt University School Of Medicine
Curated by ChEMBL
Vanderbilt University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells harboring GIRK assessed as reduction in LPA4-induced thallium flux preinc...More data for this Ligand-Target Pair