BDBM50503506 CHEMBL4517147::US10626103, Example 52

SMILES CN(C)[C@H]1CCN(C1)C(=O)c1nc(-c2ccc(C#N)c(F)c2)n(c1C)-c1cc(F)c2nn(C)cc2c1

InChI Key InChIKey=UOAGHSGZZDCNBF-IBGZPJMESA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50503506   

TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50503506(CHEMBL4517147 | US10626103, Example 52)
Affinity DataIC50:  12nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50503506(CHEMBL4517147 | US10626103, Example 52)
Affinity DataIC50: <100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50503506(CHEMBL4517147 | US10626103, Example 52)
Affinity DataEC50:  45nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of CD11b expression after 4 days by LIVE/DEAD violet staining based FACS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed