BDBM50506787 CHEMBL4558658

SMILES COc1cc2nc(NCc3ccc(F)cc3)nc(NC3CCN(CC3)C(=O)OC(C)(C)C)c2cc1OC

InChI Key InChIKey=GKSSCIXMPFNZDV-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50506787   

TargetDNA (cytosine-5)-methyltransferase 3A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50506787(CHEMBL4558658)
Affinity DataEC50:  8.70E+3nMAssay Description:Inhibition of recombinant human DNMT3a C-terminal catalytic domain (623 to 908 residues) using 5'-biotinylated/3'-FAM-oligonucleotide as substrate me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50506787(CHEMBL4558658)
Affinity DataEC50:  1.37E+5nMAssay Description:Inhibition of recombinant human N-terminal GST-fused G9a (786 to 1210 residues) expressed in Escherichia coli using biotinylated H3 (1 to 21 residues...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50506787(CHEMBL4558658)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of recombinant human DNMT1 using biotinylated DNA duplex as substrate measured after 2 hrs in presence of Adomet/[methyl-3H]Adomet by topc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed