BDBM50508763 CHEMBL4521173::US11312713, Example 6

SMILES CN1CC[C@H](C1)n1c(Cc2cc(C)ncn2)nc2cnc3ccc(cc3c12)C#N

InChI Key InChIKey=NZGUBUFNKSWTBS-QGZVFWFLSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50508763   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50508763(CHEMBL4521173 | US11312713, Example 6)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of recombinant wild-type GST-tagged LRRK2 (unknown origin) expressed in baculovirus expression system using fluorescein-labeled LRRKtide a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50508763(CHEMBL4521173 | US11312713, Example 6)
Affinity DataIC50:  11.3nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50508763(CHEMBL4521173 | US11312713, Example 6)
Affinity DataIC50:  6.39nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50508763(CHEMBL4521173 | US11312713, Example 6)
Affinity DataIC50:  11nMAssay Description:Inhibition of GST-tagged LRRK2 G2019S mutant (unknown origin) expressed in baculovirus expression system using fluorescein-labeled LRRKtide as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed