BDBM50512346 CHEMBL4464404

SMILES C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(cc3)N3CCOCC3)nc3[nH]cc(-c4ccncc4)c23)c1

InChI Key InChIKey=YWNSSPVFNHFVBC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50512346   

TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50512346(CHEMBL4464404)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged ITK (352 to 617 residues) expressed in baculovirus infected Sf21 insect cells using STK substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50512346(CHEMBL4464404)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR kinase domain (696 to end residues) expressed in baculovirus infected Sf21 insect cells us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50512346(CHEMBL4464404)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged BTK expressed in baculovirus infected Sf21 insect cells using STK substrate by HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50512346(CHEMBL4464404)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged JAK3 (781 to end residues) expressed in baculovirus infected Sf21 cells using STK as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50512346(CHEMBL4464404)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of BLK (unknown origin) using STK as substrate by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed