BDBM50513869 CHEMBL4449013

SMILES COc1n[nH]c2ncc(cc12)-c1cn(nn1)-c1c(F)ccc(NS(=O)(=O)c2cccc(c2)C(C)C)c1F

InChI Key InChIKey=RDDZCQXKIJXMQN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50513869   

TargetMitogen-activated protein kinase kinase kinase 20(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50513869(CHEMBL4449013)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human full-length ZAK expressed in baculovirus infected Sf9 insect cells using MBP as substrate after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50513869(CHEMBL4449013)
Affinity DataIC50:  190nMAssay Description:Inhibition of recombinant human B-RAF V600E mutant using Ser/Thr3 as substrate after 1 hr by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed