BDBM50517283 CHEMBL425281

SMILES CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI Key InChIKey=GNKDKYIHGQKHHM-RJKLHVOGSA-N

Data  1 KI  8 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50517283   

TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50517283(CHEMBL425281)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAppetite-regulating hormone(Homo sapiens (Human))
Tongji University

Curated by ChEMBL
LigandPNGBDBM50517283(CHEMBL425281)
Affinity DataIC50:  2.20nMAssay Description:Displacement of C-terminal Cys-tagged SmBiT tracer from C-terminal Cys-tagged human Ghrelin expressed in HEK293T cells by microplate reader based Nan...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAppetite-regulating hormone(Homo sapiens (Human))
Tongji University

Curated by ChEMBL
LigandPNGBDBM50517283(CHEMBL425281)
Affinity DataIC50:  2.20nMAssay Description:Displacement of C-terminal Cys-tagged SmBiT tracer from C-terminal Cys-tagged human Ghrelin expressed in HEK293T cells by microplate reader based Nan...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAppetite-regulating hormone(Homo sapiens (Human))
Tongji University

Curated by ChEMBL
LigandPNGBDBM50517283(CHEMBL425281)
Affinity DataIC50:  3.60nMAssay Description:Displacement of C-terminal Cys-tagged human LEAP2-SmBiT tracer from C-terminal Cys-tagged human Ghrelin expressed in HEK293T cells by microplate read...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAppetite-regulating hormone(Bos taurus)
Tongji University

Curated by ChEMBL
LigandPNGBDBM50517283(CHEMBL425281)
Affinity DataIC50:  12nMAssay Description:Binding affinity to Ghrelin in fetal bovine serum expressed in HEK293T cells using NanoLuc as substrate measured after 1 hr by bioluminescence based ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAppetite-regulating hormone(Homo sapiens (Human))
Tongji University

Curated by ChEMBL
LigandPNGBDBM50517283(CHEMBL425281)
Affinity DataEC50:  2nMAssay Description:Displacement of C-terminal Cys-tagged NanoLuc luciferase from C-terminal Cys-tagged human Ghrelin expressed in HEK293T cells by microplate reader bas...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAppetite-regulating hormone(Homo sapiens (Human))
Tongji University

Curated by ChEMBL
LigandPNGBDBM50517283(CHEMBL425281)
Affinity DataEC50:  1.90nMAssay Description:Displacement of C-terminal Cys-tagged NanoLuc luciferase from C-terminal Cys-tagged human Ghrelin expressed in HEK293T cells by microplate reader bas...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAppetite-regulating hormone(Homo sapiens (Human))
Tongji University

Curated by ChEMBL
LigandPNGBDBM50517283(CHEMBL425281)
Affinity DataIC50:  12nMAssay Description:Binding affinity to Ghrelin in human serum expressed in HEK293T cells using NanoLuc as substrate measured after 1 hr by bioluminescence based micropl...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAppetite-regulating hormone(Homo sapiens (Human))
Tongji University

Curated by ChEMBL
LigandPNGBDBM50517283(CHEMBL425281)
Affinity DataIC50:  12nMAssay Description:Binding affinity to Ghrelin in human serum expressed in HEK293T cells using NanoLuc as substrate measured after 1 hr by bioluminescence based micropl...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAppetite-regulating hormone(Bos taurus)
Tongji University

Curated by ChEMBL
LigandPNGBDBM50517283(CHEMBL425281)
Affinity DataIC50:  12nMAssay Description:Binding affinity to Ghrelin in fetal bovine serum expressed in HEK293T cells using NanoLuc as substrate measured after 1 hr by bioluminescence based ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50517283(CHEMBL425281)
Affinity DataEC50:  1.5nMAssay Description:Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAppetite-regulating hormone(Homo sapiens (Human))
Tongji University

Curated by ChEMBL
LigandPNGBDBM50517283(CHEMBL425281)
Affinity DataIC50:  3.5nMAssay Description:Displacement of C-terminal Cys-tagged human LEAP2-SmBiT tracer from C-terminal Cys-tagged human Ghrelin expressed in HEK293T cells by microplate read...More data for this Ligand-Target Pair
In DepthDetails PubMed