BDBM50529313 Flumatinib::HH-GV678::Hhgv-678

SMILES CN1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2cnc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1

InChI Key InChIKey=BJCJYEYYYGBROF-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50529313   

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50529313(Flumatinib | HH-GV678 | Hhgv-678)
Affinity DataIC50:  22nMAssay Description:Inhibition of BCR/Abl M351T mutant (unknown origin) transfected in mouse Ba/F3 cells assessed as inhibition of cell proliferation measured after 72 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50529313(Flumatinib | HH-GV678 | Hhgv-678)
Affinity DataIC50:  18nMAssay Description:Inhibition of BCR/Abl Q252H mutant (unknown origin) transfected in mouse Ba/F3 cells assessed as inhibition of cell proliferation measured after 72 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50529313(Flumatinib | HH-GV678 | Hhgv-678)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of wild type BCR/Abl (unknown origin) transfected in mouse Ba/F3 cells assessed as inhibition of cell proliferation measured after 72 hrs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50529313(Flumatinib | HH-GV678 | Hhgv-678)
Affinity DataIC50:  666nMAssay Description:Inhibition of c-Kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50529313(Flumatinib | HH-GV678 | Hhgv-678)
Affinity DataIC50:  318nMAssay Description:Inhibition of BCR/Abl Y253F mutant (unknown origin) transfected in mouse Ba/F3 cells assessed as inhibition of cell proliferation measured after 72 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50529313(Flumatinib | HH-GV678 | Hhgv-678)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of BCR-ABL phosphorylation in human K562 cells incubated for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50529313(Flumatinib | HH-GV678 | Hhgv-678)
Affinity DataIC50:  308nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50529313(Flumatinib | HH-GV678 | Hhgv-678)
Affinity DataIC50:  14nMAssay Description:Inhibition of BCR/Abl F317I mutant (unknown origin) transfected in mouse Ba/F3 cells assessed as inhibition of cell proliferation measured after 72 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed