BDBM50530381 CHEMBL4516272

SMILES CN(C)C(=O)c1cnc(Nc2ccc(F)cn2)cc1Nc1ccccc1C(N)=O

InChI Key InChIKey=YWUIKGIJIWMCCI-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50530381   

LigandPNGBDBM50530381(CHEMBL4516272)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50530381(CHEMBL4516272)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1/JAK2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50530381(CHEMBL4516272)
Affinity DataIC50: >1.25E+4nMAssay Description:Inhibition of JAK1/JAK2 (unknown origin) in GM-CSF stimulated cells by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50530381(CHEMBL4516272)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50530381(CHEMBL4516272)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50530381(CHEMBL4516272)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1/JAK2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50530381(CHEMBL4516272)
Affinity DataIC50: >1.25E+4nMAssay Description:Inhibition of JAK1/JAK2 (unknown origin) in GM-CSF stimulated cells by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50530381(CHEMBL4516272)
Affinity DataIC50:  87nMAssay Description:Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50530381(CHEMBL4516272)
Affinity DataIC50:  87nMAssay Description:Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50530381(CHEMBL4516272)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50530381(CHEMBL4516272)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50530381(CHEMBL4516272)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetJAK3/JAK1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50530381(CHEMBL4516272)
Affinity DataIC50: >1.25E+4nMAssay Description:Inhibition of JAK1/JAK3 (unknown origin) in IL-2 stimulated cells by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50530381(CHEMBL4516272)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetJAK3/JAK1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50530381(CHEMBL4516272)
Affinity DataIC50: >1.25E+4nMAssay Description:Inhibition of JAK1/JAK3 (unknown origin) in IL-2 stimulated cells by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50530381(CHEMBL4516272)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed