BDBM50533687 CHEMBL4463043

SMILES NC(=O)c1cnc(Nc2ccncn2)cc1NC1CCN(CC1)c1ccc(cn1)C#N

InChI Key InChIKey=LGSRWIXAYAGSJU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50533687   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50533687(CHEMBL4463043)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of human JAK1 assessed as reduction in phosphorylation of Biotin-Lyn-Substrate-2 after 1 hr in presence of ATP by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50533687(CHEMBL4463043)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of human JAK2 assessed as reduction in phosphorylation of Biotin-Lyn-Substrate-2 after 1 hr in presence of ATP by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50533687(CHEMBL4463043)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells after 10 mins by Rb efflux assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50533687(CHEMBL4463043)
Affinity DataIC50:  0.610nMAssay Description:Inhibition of human JAK3 assessed as reduction in phosphorylation of Biotin-Lyn-Substrate-2 after 1 hr in presence of ATP by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed