BDBM50538503 CHEMBL4645108

SMILES Fc1ccc(NC(=O)C2(COC2)c2ccc(NC(=O)c3cccc(Cl)c3)cc2)cc1

InChI Key InChIKey=MFKLGMRXGXACFK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50538503   

TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50538503(CHEMBL4645108)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of heme binding to IDO1 in interferon-gamma-induced human HeLa cells assessed as reduction in N-formylkynurenine production using L-trypto...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50538503(CHEMBL4645108)
Affinity DataIC50:  9.09E+6nMAssay Description:Inhibition of MK-499 binding to hERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50538503(CHEMBL4645108)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of IDO1 in IFNgamma/LPS stimulated human whole blood assessed as unbound concentration using kynurenine/tryptophan as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50538503(CHEMBL4645108)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of IDO1 in IFN gamma-stimulated human HeLa cells measured after 48 hrs by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed