BDBM50541626 CHEMBL4646589

SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@@H](N)Cc1cn(CCCC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@]3([H])CCCN3C(=O)[C@H](Cc3c[nH]cn3)NC2=O)C(N)=O)nn1

InChI Key InChIKey=YQXDFRDKAUUILW-YJXWTMGESA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50541626   

Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50541626(CHEMBL4646589)
Affinity DataIC50:  20nMAssay Description:Inhibition of proMMP2 activation in human WM115 cells assessed as reduction in MMP2 activity at 0.1 nM to 1 uM incubated for 24 hrs by gelatin zymogr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50541626(CHEMBL4646589)
Affinity DataKd:  1nMAssay Description:Binding affinity to fluorescein-labeled D570-A583 epitope of human MMP2 expressed in Escherichia coli BL21(DE3) RIL incubated for 30 mins by competit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50541626(CHEMBL4646589)
Affinity DataKd:  2.30nMAssay Description:Binding affinity to N-terminal (His6)-MBP tagged full-length human proMMP2 expressed in Escherichia coli BL21(DE3) RIL assessed as reduction in Rhod-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed