BDBM50546065 CHEMBL4795177

SMILES COc1nnc2sc(C(=O)NC3CN(C3)c3ncc(cn3)C(F)(F)F)c(N)c2c1C

InChI Key InChIKey=VILQHBIGBISKQM-UHFFFAOYSA-N

Data  4 IC50  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50546065   

TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546065(CHEMBL4795177)
Affinity DataEC50:  90nMAssay Description:Positive allosteric modulation of human M4 receptor/Gqi5 in presence of EC20 glutamate by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546065(CHEMBL4795177)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human M2 receptor/Gqi5 in presence of EC20 glutamate by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546065(CHEMBL4795177)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546065(CHEMBL4795177)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human M3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546065(CHEMBL4795177)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human M5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(RAT)
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546065(CHEMBL4795177)
Affinity DataEC50:  28nMAssay Description:Positive allosteric modulation of rat M4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546065(CHEMBL4795177)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546065(CHEMBL4795177)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of rat M3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(RAT)
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546065(CHEMBL4795177)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of rat M5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546065(CHEMBL4795177)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546065(CHEMBL4795177)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546065(CHEMBL4795177)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546065(CHEMBL4795177)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of rat M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed