BDBM50555779 CHEMBL4800354
SMILES FC(F)(F)c1cccc(n1)-c1nc2NCCOCCCCc3cc(Cl)cc(Nc(n2)n1)c3
InChI Key InChIKey=SEWADTGOHXMXQV-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50555779
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Homo sapiens (Human))
Hangzhou Institute Of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute Of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-ketoglutarate and NADPH as substrate preincub...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Homo sapiens (Human))
Hangzhou Institute Of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute Of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of wild type IDH2 (unknown origin) assessed as reduction in NADPH production using sodium(D)-isocitrate and NADP as substrate preincubated...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Homo sapiens (Human))
Hangzhou Institute Of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute Of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 443nMAssay Description:Inhibition of IDH2 R172K mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-ketoglutarate and NADPH as substrate preincub...More data for this Ligand-Target Pair