BDBM50556041 CHEMBL4779761

SMILES NC1=N[C@@](CF)(C[S@@]2(=O)=NCCCCN12)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F

InChI Key InChIKey=KJBWPUVDNODFAY-AUSOSSAASA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50556041   

TargetBeta-secretase 1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556041(CHEMBL4779761)
Affinity DataIC50:  28nMAssay Description:Inhibition of BACE1 in HEK293 cells harboring APP assessed as reduction in amyloidbeta 40 level measured after 18 to 20 hrs by AlphaLISA AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed