BDBM50558112 CHEMBL4799627
SMILES CC1(COC1)C(=O)N1CCC[C@H](C1)c1nc(-c2ccc(cc2F)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
InChI Key InChIKey=XYFZVVYVIFJBIS-QGZVFWFLSA-N
Data 19 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 19 hits for monomerid = 50558112
Affinity DataIC50: 0.320nMAssay Description:Reversible inhibition of recombinant full length BTK (unknown origin) baculovirus infected Sf9 cells using biotinylated EQEDEPEGDYFEWLE-NH2 peptide a...More data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Inhibition of human YES1More data for this Ligand-Target Pair
Affinity DataIC50: 113nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in cell surface CD69 expression preincubated for 1 hr followed by stimulation with anti-...More data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of human BLKMore data for this Ligand-Target Pair
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human BMXMore data for this Ligand-Target Pair
Affinity DataIC50: 253nMAssay Description:Inhibition of human CSKMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 81nMAssay Description:Inhibition of human ERBB4More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Inhibition of human FGRMore data for this Ligand-Target Pair
Affinity DataIC50: 187nMAssay Description:Inhibition of human FRKMore data for this Ligand-Target Pair
Affinity DataIC50: 322nMAssay Description:Inhibition of human FYNMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 921nMAssay Description:Inhibition of human ITKMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of human LCKMore data for this Ligand-Target Pair
Affinity DataIC50: 184nMAssay Description:Inhibition of human LYNBMore data for this Ligand-Target Pair
Affinity DataIC50: 63nMAssay Description:Inhibition of human PTK6More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 116nMAssay Description:Inhibition of human SRCMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Srms(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of human SRMSMore data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:Inhibition of human TECMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of human TXKMore data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in cell surface CD69 expression preincubated for 1 hr followed by stimulation with goat anti-hu...More data for this Ligand-Target Pair