BDBM50563533 CHEMBL4777288

SMILES CC(C)(C)c1ccc(cc1)-c1coc2ccc(nc12)-c1cn[nH]c1

InChI Key InChIKey=OOLXXVMFVSTNLJ-UHFFFAOYSA-N

Data  21 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50563533   

TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CLK1 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetCyclin-dependent kinase-like 3(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CDKL3 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50:  1.43E+3nMAssay Description:Inhibition of human recombinant CLK2 using YRRAAVPPSPSLSR substrate by radiometric scintillation assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of human full length recombinant CLK3 using ERMRPRKRQGSVR substrate by radiometric scintillation assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50:  1.47E+3nMAssay Description:Inhibition of human recombinant CLK4 using YRRAAVPPSPSLS substrate by radiometric scintillation assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of human full length recombinant DYRK1A using RRRFRPASPLRGPP substrate by radiometric scintillation assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of human full length recombinant DYRK1B using RRRFRPASPLRGPP substrate by radiometric scintillation assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of human full length recombinant DYRK2 using casein substrate by radiometric scintillation assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetHomeodomain-interacting protein kinase 1(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50:  248nMAssay Description:Inhibition of human recombinant HIPK1 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetHomeodomain-interacting protein kinase 2(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50:  119nMAssay Description:Inhibition of human recombinant HIPK2 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetHomeodomain-interacting protein kinase 3(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50:  476nMAssay Description:Inhibition of human recombinant HIPK3 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of CLK2 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50:  4.30E+4nMAssay Description:Inhibition of CLK3 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition of CLK4 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50:  4.30E+4nMAssay Description:Inhibition of DYRK1A (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of DYRK1B (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of DYRK2 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of MLK1 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetMitogen-activated protein kinase kinase kinase 10(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of MLK2 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of MLK3 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

Target InfoPDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

LigandBDBM50563533(CHEMBL4777288)Copy SMILESCopy InChI

Affinity DataIC50:  946nMAssay Description:Inhibition of human recombinant CLK1 using ERMRPRKRQGSVR substrate by radiometric scintillation assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI