BDBM50569790 CHEMBL4852459

SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)NCCNC(=O)C=C)c([nH]c1=O)c23

InChI Key InChIKey=PNEMIRUDKPQJSM-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50569790   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50569790(CHEMBL4852459)
Affinity DataKi:  52nMAssay Description:Covalent inhibition of recombinant human GST-tagged BTK (2 to 659 end residues) expressed in baculovirus expression system assessed as inhibition con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Mus musculus)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50569790(CHEMBL4852459)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of BTK in C57Bl/6 mouse splenocyte assessed as reduction in anti-IgM-induced CD69 expression incubated for 1 hr followed anti-IgM stimulat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed