BDBM50571573 CHEMBL4863993

SMILES Clc1cnc(CNc2cc3sncc3cc2Cl)s1

InChI Key InChIKey=GFNMKESSHVFPQM-UHFFFAOYSA-N

Data  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50571573   

TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Aptuit, An Evotec

Curated by ChEMBL
LigandPNGBDBM50571573(CHEMBL4863993)
Affinity DataEC50:  3.16E+3nMAssay Description:Agonist activity at human TRPA1 expressed in HEK cells assessed as increase in menthol-induced intracellular calcium level incubated for 2 hrs by FLI...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Aptuit, An Evotec

Curated by ChEMBL
LigandPNGBDBM50571573(CHEMBL4863993)
Affinity DataEC50: <1.58E+4nMAssay Description:Agonist activity at human TRPV4 expressed in HEK cells assessed as increase in GSK1016790A-induced intracellular calcium level measured after 1 hr by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Aptuit, An Evotec

Curated by ChEMBL
LigandPNGBDBM50571573(CHEMBL4863993)
Affinity DataEC50: <1.58E+4nMAssay Description:Agonist activity at human TRPV1 expressed in CHO cells assessed as increase in capsaicin-induced intracellular calcium level measured after 1 hr by F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 5(Homo sapiens (Human))
Turning Point Therapeutics

Curated by ChEMBL
LigandPNGBDBM50571573(CHEMBL4863993)
Affinity DataEC50:  7.90nMAssay Description:Agonist activity at human TRPM5 expressed in CHO-K1 cells assessed as increase in relative fluorescence unit measured for 2 mins by FLIPR based membr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransient receptor potential cation channel subfamily M member 5(Homo sapiens (Human))
Turning Point Therapeutics

Curated by ChEMBL
LigandPNGBDBM50571573(CHEMBL4863993)
Affinity DataEC50:  7.90nMAssay Description:Agonist activity at human TRPM5 expressed in CHO-K1 cells maintained at 80 mV final holding potential by syncroPatch assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 5(Mus musculus)
Aptuit, An Evotec

Curated by ChEMBL
LigandPNGBDBM50571573(CHEMBL4863993)
Affinity DataEC50:  16nMAssay Description:Agonist activity at mouse TRPM5 expressed in CHO-K1 cells maintained at 80 mV final holding potential by syncroPatch assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 4(Homo sapiens)
Aptuit, An Evotec

Curated by ChEMBL
LigandPNGBDBM50571573(CHEMBL4863993)
Affinity DataEC50:  3.16E+3nMAssay Description:Agonist activity at human TRPM4 expressed in CHO cells assessed as increase in A23187-induced intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Aptuit, An Evotec

Curated by ChEMBL
LigandPNGBDBM50571573(CHEMBL4863993)
Affinity DataEC50: <1.58E+4nMAssay Description:Agonist activity at human TRPM8 expressed in HEK cells assessed as increase in menthol-induced intracellular calcium level measured after 1 hr by FLI...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed