BDBM50575569 CHEMBL4866755

SMILES Cc1cccc(Cn2ccc(n2)C(=O)c2cncnc2N[C@H]2C[C@H](O)[C@@H](COS(N)(=O)=O)C2)c1

InChI Key InChIKey=IXCWIEAIJGSNQZ-HLIPFELVSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50575569   

TargetSUMO-activating enzyme subunit 1/2(Homo sapiens (Human))
Millennium Pharmaceuticals, A Wholly Owned Subsidiary Of Takeda Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50575569(CHEMBL4866755)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of recombinant SAE (unknown origin) assessed as reduction in transfer of SUMO1 to UBC9 using SUMO1 as a substrate in presence of ATP at Km...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSUMO-activating enzyme subunit 1/2(Homo sapiens (Human))
Millennium Pharmaceuticals, A Wholly Owned Subsidiary Of Takeda Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50575569(CHEMBL4866755)
Affinity DataIC50:  29nMAssay Description:Inhibition of SAE in human HCT116 cells assessed as reduction in redistribution of SUMO2/3 proteins from nucleus to cytosol incubated for 4 hrs by im...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Millennium Pharmaceuticals, A Wholly Owned Subsidiary Of Takeda Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50575569(CHEMBL4866755)
Affinity DataIC50:  308nMAssay Description:Inhibition of recombinant NAE (unknown origin) in presence of ATP at Km concentration by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed