BDBM50579589 CHEMBL4859820
SMILES CC(C)c1nccc(C)c1-n1c2nc(c(Cl)cc2c(N2CCN(CC2)C(=O)C=C)c(C#N)c1=O)-c1c(N)c(Cl)cc(Cl)c1F
InChI Key InChIKey=IBNSEKBMYPAXNN-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50579589
Affinity DataIC50: 1.90nMAssay Description:Inhibition of GDP-loaded His-tagged KRAS G12C mutant (2 to 182 residues) (unknown origin) assessed as inhibition of SOS1-catalyzed nucleotide exchang...More data for this Ligand-Target Pair
Affinity DataIC50: 10.4nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 2 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 2 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.95nMAssay Description:Inhibition of GDP-loaded His-tagged KRAS G12C mutant (2 to 182 residues) (unknown origin) assessed as inhibition of SOS1-catalyzed nucleotide exchang...More data for this Ligand-Target Pair