BDBM50585402 CHEMBL5081048

SMILES [H][C@]12CC[C@]([H])(CN(C1)c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c(F)c(ncc13)-c1cc(O)cc3ccc(F)c(C#C)c13)N2

InChI Key InChIKey=SCLLZBIBSFTLIN-INOGPEIASA-N

Data  2 IC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50585402   

TargetGTPase KRas(Homo sapiens (Human))
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM50585402(CHEMBL5081048)
Affinity DataIC50:  5nMAssay Description:Inhibition of human GDP-bound KRAS G12D mutant assessed as inhibition of SOS1-catalyzed nucleotide exchange by measuring KRAS G12D mutant/GTP/c-Raf1 ...More data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM50585402(CHEMBL5081048)
Affinity DataIC50:  2nMAssay Description:Inhibition of KRAS G12D mutant in human AGS cells assessed as reduction in ERK phosphorylation measured after 3 hrs by In-Cell Western assayMore data for this Ligand-Target Pair