BDBM50594973 CHEMBL5169811

SMILES Nc1nc(nc2n(C[C@H]3CN(Cc4nccs4)CCO3)nnc12)C(F)(F)F

InChI Key InChIKey=VNLPYEMGHGDRRZ-MRVPVSSYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50594973   

LigandPNGBDBM50594973(CHEMBL5169811)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of PDE8A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50594973(CHEMBL5169811)
Affinity DataIC50: <0.300nMAssay Description:Inhibition of PDE8B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50594973(CHEMBL5169811)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50594973(CHEMBL5169811)
Affinity DataIC50:  0.300nMAssay Description:Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50594973(CHEMBL5169811)
Affinity DataIC50:  0.700nMAssay Description:Antagonist activity at human EP1 receptor expressed in CHO cells receptor by NFTA reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50594973(CHEMBL5169811)
Affinity DataIC50:  0.700nMAssay Description:Antagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed