BDBM50600516 CHEMBL5186861

SMILES NC(=O)c1cc2c(cccc2s1)-c1ccc(s1)C(=O)NCc1ccccc1N

InChI Key InChIKey=UQZFCZAYARDQIK-UHFFFAOYSA-N

Data  3 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50600516   

LigandPNGBDBM50600516(CHEMBL5186861)
Affinity DataKi:  68nMAssay Description:Inhibition of human DYRK1A incubated for 90 mins in presence of ATP by Z-LYTE based FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50600516(CHEMBL5186861)
Affinity DataKi:  238nMAssay Description:Inhibition of human DYRK1B incubated for 130 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase PRP4 homolog(Homo sapiens (Human))
Ach£

Curated by ChEMBL
LigandPNGBDBM50600516(CHEMBL5186861)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of DNA-tagged human PRP4 expressed in Escherichia coli incubated for 1.5 hrs by KINOMEscan assayMore data for this Ligand-Target Pair
LigandPNGBDBM50600516(CHEMBL5186861)
Affinity DataIC50:  800nMAssay Description:Inhibition of NanoLuc-fused human DYRK1B expressed in HEK293T cells using Nano-Glo as substrate incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50600516(CHEMBL5186861)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of NanoLuc-fused human DYRK1A expressed in HEK293 cells using Nano-Glo as substrate incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed