BDBM50600940 CHEMBL5081846

SMILES Nc1c(cnn1-c1ccc(OC(F)(F)F)cc1)C(=O)C1CCNCC1

InChI Key InChIKey=OOUGXIZAHWLQEM-UHFFFAOYSA-N

Data  1 IC50  2 Kd  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50600940   

TargetSerine protease inhibitor A3N(Mus musculus)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50600940(CHEMBL5081846)
Affinity DataEC50:  6.27E+3nMAssay Description:Inhibition of SerpinA3n in mouse ScN2a cells infected with 22L prion assessed as reduction of PrPSc accumulation measured after 3 days by densitometr...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine protease inhibitor A3N(Mus musculus)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50600940(CHEMBL5081846)
Affinity DataKd:  2.60E+4nMAssay Description:Binding affinity to C-terminal His-tagged mouse recombinant SerpinA3n expressed in Escherichia coli BL21(DE3) pLysS cells assessed as dissociation co...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine protease inhibitor A3N(Mus musculus)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50600940(CHEMBL5081846)
Affinity DataKd:  1.40E+3nMAssay Description:Binding affinity to C-terminal His-tagged mouse recombinant SerpinA3n expressed in Escherichia coli BL21(DE3) pLysS cells assessed as dissociation co...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMajor prion protein(Mus musculus)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50600940(CHEMBL5081846)
Affinity DataIC50:  950nMAssay Description:Synergistic anti-prion activity of mouse ScN2a cells infected with RML prion assessed as reduction of RML accumulation by isobologram analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine protease inhibitor A3N(Mus musculus)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50600940(CHEMBL5081846)
Affinity DataEC50:  1.93E+4nMAssay Description:Inhibition of SerpinA3n in mouse ScGT1 cells infected with 22L prion assessed as reduction of PrPSc accumulation measured after 3 days by densitometr...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine protease inhibitor A3N(Mus musculus)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50600940(CHEMBL5081846)
Affinity DataEC50:  1.12E+4nMAssay Description:Inhibition of SerpinA3n in mouse ScN2a cells infected with RML prion assessed as reduction of PrPSc accumulation measured after 3 days by densitometr...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine protease inhibitor A3N(Mus musculus)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50600940(CHEMBL5081846)
Affinity DataEC50:  8.64E+3nMAssay Description:Inhibition of SerpinA3n in mouse ScGT1 cells infected with RML prion assessed as reduction of PrPSc accumulation measured after 3 days by densitometr...More data for this Ligand-Target Pair
In DepthDetails PubMed