BDBM50601245 CHEMBL5196139

SMILES S=c1cc(Cc2ccccn2)[nH]c2nc(Nc3c4CCCc4cc4CCCc34)nn12

InChI Key InChIKey=BHTLYBBOAZYXBF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50601245   

TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Nodthera

Curated by ChEMBL
LigandPNGBDBM50601245(CHEMBL5196139)
Affinity DataIC50:  13nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-pretreated PBMC (unknown origin) assessed as reduction in IL-1beta release pretreated for 30 mins followed by...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Nodthera

Curated by ChEMBL
LigandPNGBDBM50601245(CHEMBL5196139)
Affinity DataIC50:  34nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-pretreated human THP1-ASC-GFP cells assessed as reduction in speck positive cells measured after 30 mins in p...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Nodthera

Curated by ChEMBL
LigandPNGBDBM50601245(CHEMBL5196139)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-pretreated human whole blood assessed as reduction in IL-1beta release pretreated for 30 mins followed by ATP...More data for this Ligand-Target Pair
In DepthDetails PubMed