BDBM50602803 CHEMBL5169523

SMILES CN(C)C\C=C\C(=O)N1CCC(CC1)Nc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4ccc5cnccc5c4)ccc3C)cn2)c1

InChI Key InChIKey=AWZWOMPLEBTAGQ-VMPITWQZSA-N

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50602803   

TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50602803(CHEMBL5169523)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of wild type N-terminal GST tagged BLK (unknown origin) (1 to 505 residues) expressed in sf21 insect cell using TK as substrate incubated ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50602803(CHEMBL5169523)
Affinity DataIC50:  202nMAssay Description:Inhibition of wild type N-terminal GST tagged BTK (unknown origin) (2 to 659 residues) expressed in sf21 insect cell using TK as substrate incubated ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50602803(CHEMBL5169523)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of BTK in goat anti-human IgM antibody stimulated human Ramos cells assessed as PLCgamma2 phosphorylation preincubated for 1 hr followed b...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50602803(CHEMBL5169523)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of BTK in goat anti-human IgM antibody stimulated human Ramos cells assessed as BTK autophosphorylation at Tyr233 residue preincubated for...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50602803(CHEMBL5169523)
Affinity DataIC50:  12nMAssay Description:Inhibition of (S)-3-(3-(5-acrylamido-6-(3-(5-(2-methyl-5-(3-(trifluoromethyl)benzamido)benzamido)pyrimidin-2-ylamino)phenylamino)-6-oxohexylamino)-3-...More data for this Ligand-Target Pair
In DepthDetails PubMed