BDBM50604569 CHEMBL5170051

SMILES CC(C)C[C@H](Nc1ncnc(Nc2ccc(NC(C)=O)cc2)n1)C(O)=O

InChI Key InChIKey=DBJHDAUCEOBOBM-AWEZNQCLSA-N

Data  6 IC50  1 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50604569   

TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50604569(CHEMBL5170051)
Affinity DataEC50:  2.22E+4nMAssay Description:Agonist activity at NPRC in rat small mesenteric arteries assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50604569(CHEMBL5170051)
Affinity DataEC50:  6.20E+3nMAssay Description:Agonist activity at NPRC in rat aorta assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50604569(CHEMBL5170051)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by NADPH addition and measured after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50604569(CHEMBL5170051)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated for 10 mins followed by NADPH addition and measured aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50604569(CHEMBL5170051)
Affinity DataKd:  2.20E+5nMAssay Description:Binding affinity to CM5 sensor chip immobilized human NPR-C (27 to 541 residues) assessed as dissociation constant by surface plasmon resonance analy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50604569(CHEMBL5170051)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as a substrate preincubated for 10 mins followed by NADPH addition and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50604569(CHEMBL5170051)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as a substrate preincubated for 10 mins followed by NADPH addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50604569(CHEMBL5170051)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as a substrate preincubated for 10 mins followed by NADPH addition and measured aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50604569(CHEMBL5170051)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 10 mins followed by NADPH addition and measured after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed