BDBM50610162 CHEMBL5286386

SMILES CC(C)(O)c1ccc(NC(=O)c2cc(C(=O)NCc3ccc(F)c(F)c3)c(F)cc2Cl)cc1

InChI Key InChIKey=UBFZZQYNCOPFNS-UHFFFAOYSA-N

Data  9 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50610162   

LigandPNGBDBM50610162(CHEMBL5286386)
Affinity DataEC50:  32nMAssay Description:Inverse agonist activity at GST tagged human PPARgamma LBD (231 to 505 residues) expressed in Escherichia coli BL21(DE3) assessed as recruitment of f...More data for this Ligand-Target Pair
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LigandPNGBDBM50610162(CHEMBL5286386)
Affinity DataIC50:  15nMAssay Description:Inverse agonist activity at human PPARgamma in human RT112/84 transfected with NLuc-fused FABP4 assessed as reduction in PPARgamma transactivation in...More data for this Ligand-Target Pair
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TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))TBA
LigandPNGBDBM50610162(CHEMBL5286386)
Affinity DataIC50: >4.98E+4nMAssay Description:Transactivation of human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as increase in luciferase a...More data for this Ligand-Target Pair
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LigandPNGBDBM50610162(CHEMBL5286386)
Affinity DataIC50:  28nMAssay Description:Inverse agonist activity at human PPARgamma expressed in CHO cells co-expressing GAL4-NHR-LBD assessed as transcriptional repression preincubated for...More data for this Ligand-Target Pair
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LigandPNGBDBM50610162(CHEMBL5286386)
Affinity DataIC50:  73nMAssay Description:Inverse agonist activity at PPARgamma in mouse 3T3-L1 adipocytes assessed as inhibition of adipogenesis by measuring lipid droplet staining by BODIPY...More data for this Ligand-Target Pair
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LigandPNGBDBM50610162(CHEMBL5286386)
Affinity DataIC50: >1.60E+4nMAssay Description:Inverse agonist activity at human PPARdelta expressed in CHO cells co-expressing GAL4-NHR-LBD assessed as transcriptional repression preincubated for...More data for this Ligand-Target Pair
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TargetBile acid receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50610162(CHEMBL5286386)
Affinity DataIC50: >5.00E+3nMAssay Description:Inverse agonist activity at human FXR expressed in CHO cells co-expressing GAL4-NHR-LBD assessed as transcriptional repression preincubated for 6 hrs...More data for this Ligand-Target Pair
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TargetThyroid hormone receptor alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50610162(CHEMBL5286386)
Affinity DataIC50: >5.00E+3nMAssay Description:Inverse agonist activity at human THRA expressed in CHO cells co-expressing GAL4-NHR-LBD assessed as transcriptional repression preincubated for 6 hr...More data for this Ligand-Target Pair
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TargetThyroid hormone receptor beta(Homo sapiens (Human))TBA
LigandPNGBDBM50610162(CHEMBL5286386)
Affinity DataIC50: >5.00E+3nMAssay Description:Inverse agonist activity at human THRB expressed in CHO cells co-expressing GAL4-NHR-LBD assessed as transcriptional repression preincubated for 6 hr...More data for this Ligand-Target Pair
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LigandPNGBDBM50610162(CHEMBL5286386)
Affinity DataIC50: >1.60E+4nMAssay Description:Agonist activity at human PPARalpha expressed in CHO cells co-expressing GAL4-NHR-LBD assessed as transcriptional activation preincubated for 6 hrs f...More data for this Ligand-Target Pair
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